Tuberculosis: Causes, Symptoms, and Treatments

Tuberculosis is an infectious disease that usually affects the lungs. Compared with other diseases caused by a single infectious agent, tuberculosis is the second biggest killer, globally.


In 2015, 1.8 million people died from the disease, with 10.4 million falling ill.
In the 18th and 19th centuries, a
tuberculosis epidemic rampaged throughout Europe and North America, before the German microbiologist Robert Koch discovered the microbial causes of tuberculosis in 1882.


Following Koch's discovery, the development of vaccines and effective drug treatment led to the belief that the disease was almost defeated. Indeed, at one point, the United Nations, predicted that tuberculosis (TB) would be eliminated worldwide by 2025.


However, in the mid-80s, TB cases began to rise worldwide, so much so, that in 1993, the World Health Organization (WHO) declared that TB was a global emergency ; the first time that a disease had been labeled as such.


Fortunately, with proper treatment, the vast majority of cases of tuberculosis are curable. Cases of TB have decreased in the United States since 1993, but the disease remains a concern. Without proper treatment, up to two-thirds of people ill with tuberculosis will die.


Fast facts on tuberculosis
Here are some key points about tuberculosis. More detail and supporting information is in the main article.

• The World Health Organization estimates that 9 million people a year get sick with TB, with 3 million of these "missed" by health systems

• TB is among the top 3 causes of death for women aged 15 to 44

• TB symptoms (cough, fever, night sweats, weight loss, etc.) may be mild for many months, and people ill with TB can infect up to 10-15 other people through close contact over the course of a year

• TB is an airborne pathogen, meaning that the bacteria that cause TB can spread through the air from person to person.
TB usually affects the lungs, although it can spread to other organs around the body.
Doctors make a distinction between two kinds of tuberculosis infection: latent and active.


Latent TB - the bacteria remain in the body in an inactive state. They cause no symptoms and are not contagious, but they can become active.

Active TB - the bacteria do cause symptoms and can be transmitted to others.
About one-third of the world's population is believed to have latent TB. There is a 10 percent chance of latent TB becoming active, but this risk is much higher in people who have compromised immune systems i.e., people living with HIV or malnutrition, or people who smoke.

TB affects all age groups and all parts of the world. However, the disease mostly affects young adults and people living in developing countries. In 2012, 80 percent of reported TB cases occurred in just 22 countries.


What causes tuberculosis?
The Mycobacterium tuberculosis bacterium causes TB. It is spread through the air when a person with TB (whose lungs are affected) coughs, sneezes, spits, laughs, or talks.
TB is contagious, but it is not easy to catch. The chances of catching TB from someone you live or work with are much higher than from a stranger. Most people with active TB who have received appropriate treatment for at least 2 weeks are no longer contagious.
Since antibiotics began to be used to fight TB, some strains have become resistant to drugs. Multidrug-resistant TB (MDR-TB) arises when an antibiotic fails to kill all of the bacteria, with the surviving bacteria developing resistance to that antibiotic and often others at the same time.
MDR-TB is treatable and curable only with the use of very specific anti-TB drugs, which are often limited or not readily available. In 2012, around 450,000 people developed MDR-TB.


People with compromised immune systems are most at risk of developing active tuberculosis. HIV suppresses the immune system, making it harder for the body to control TB bacteria. People who are infected with both HIV and TB are around 20-30 percent more likely to develop active TB than those who do not have HIV.
Tobacco use has also been found to increase the risk of developing active TB. Over 20 percent of TB cases worldwide are related to smoking.

Symptoms of tuberculosis
While latent TB is symptomless, the symptoms of active TB include the following:
Coughing, sometimes with mucus or blood
Chills
Fatigue
Fever
Loss of weight
Loss of appetite
Night sweats

Tuberculosis usually affects the lungs, but can also affect other parts of the body. When TB occurs outside of the lungs, the symptoms vary accordingly. Without treatment, TB can spread to other parts of the body through the bloodstream:
TB infecting the bones can lead to spinal pain and joint destruction
TB infecting the brain can cause meningitis
TB infecting the liver and kidneys can impair their waste filtration functions and lead to blood in the urine
TB infecting the heart can impair the heart's ability to pump blood, resulting in a condition called cardiac tamponade that can be fatal

Diagnosis of tuberculosis
TB is most commonly diagnosed via a skin test involving an injection in the forearm.
To check for TB, a doctor will use a stethoscope to listen to the lungs and check for swelling in the lymph nodes. They will also ask about symptoms and medical history as well as assessing the individual's risk of exposure to TB.



The most common diagnostic test for TB is a skin test where a small injection of PPD tuberculin, an extract of the TB bacterium, is made just below the inside forearm.
The injection site should be checked after 2-3 days, and, if a hard, red bump has swollen up to a specific size, then it is likely that TB is present.
Unfortunately, the skin test is not 100 percent accurate and has been known to give incorrect positive and negative readings.


However, there are other tests that are available to diagnose TB. Blood tests, chest X-rays, and sputum tests can all be used to test for the presence of TB bacteria and may be used alongside a skin test.
MDR-TB is more difficult to diagnose than regular TB. It is also difficult to diagnose regular TB in children.


Treatments for tuberculosis
The majority of TB cases can be cured when the right medication is available and administered correctly. The precise type and length of antibiotic treatment depends on a person's age, overall health, potential resistance to drugs, whether the TB is latent or active, and the location of infection (i.e. the lungs, brain, kidneys).

People with latent TB may need just one kind of TB antibiotics, whereas people with active TB (particularly MDR-TB) will often require a prescription of multiple drugs.
Antibiotics are usually required to be taken for a relatively long time. The standard length of time for a course of TB antibiotics is about 6 months .

TB medication can be toxic to the liver, and although side effects are uncommon, when they do occur, they can be quite serious. Potential side effects should be reported to a doctor and include:
Dark urine
Fever
Jaundice
Loss of appetite
Nausea and vomiting


It is important for any course of treatment to be completed fully, even if the TB symptoms have gone away. Any bacteria that have survived the treatment could become resistant to the medication that has been prescribed and could lead to developing MDR-TB in the future.
Directly observed therapy (DOT) may be recommended. This involves a healthcare worker administering the TB medication to ensure that the course of treatment is completed.


Prevention of tuberculosis

If you have active TB, a face mask can help lower the risk of the disease spreading to other people.

A few general measures can be taken to prevent the spread of active TB.
Avoiding other people by not going to school or work, or sleeping in the same room as someone, will help to minimize the risk of germs from reaching anyone else. Wearing a mask, covering the mouth, and ventilating rooms can also limit the spread of bacteria.
TB vaccination


In some countries, BCG injections are given to children in order to vaccinate them against tuberculosis. It is not recommended for general use in the U.S. because it is not effective in adults, and it can adversely influence the results of skin testing diagnoses.


The most important thing to do is to finish entire courses of medication when they are prescribed. MDR-TB bacteria are far deadlier than regular TB bacteria. Some cases of MDR-TB require extensive courses of chemotherapy, which can be expensive and cause severe adverse drug reactions in patients.


Countries with higher tuberculosis rates
The following countries have the highest TB rates , globally:
Africa - particularly West African and sub-Saharan Africa
Afghanistan
Southeast Asia - including Pakistan, India, Bangladesh, and Indonesia
China
Russia
South America
Western Pacific region - including the Philippines, Cambodia, and Vietnam
Written by James McIntosh

Written by James McIntosh
Reviewed by University of Illinois-Chicago, School of Medicine
Last updated: Wed 18 Jan 2017



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